Water treatment for the pharmaceutical
sector

Overview

Water treatment plays a vital role in the pharmaceutical sector, focusing on upholding the purity and safety of water utilized throughout various stages of drug production. This process centers on eliminating contaminants and impurities from water to adhere to regulatory standards stipulated by local authorities. The quality of water directly impacts the safety and integrity of pharmaceutical products, underscoring the necessity of employing sophisticated water treatment technologies and upholding stringent quality assurance practices. Within the pharmaceutical industry, distinct grades of water are utilized, such as purified water (PW), Water for Injection (WFI), and ultra-pure water (UPW), each requiring specific quality parameters to meet industry standards.

Application of water treatment

Pharmaceutical-grade water serves a range of vital purposes in various applications within the industry, including:

(1). Drug Formulation: Water serves as a solvent in the manufacturing of liquid formulations, ensuring the uniform distribution of active pharmaceutical ingredients (APIs).
(2). Sterilization Processes: Water is integral in steam sterilizers (autoclaves) for the sterilization of equipment, containers, and instruments.
(3). Cleaning and Rinsing: Purified water is indispensable for cleaning and rinsing equipment and containers to prevent contamination.
(4). Analytical Testing: High-purity water is a necessity for accurate and reliable analytical testing procedures.
(5). Production of Active Pharmaceutical Ingredients (APIs): Water of exceptional purity is essential during the synthesis of APIs to prevent impurities from compromising chemical reactions.

The dairy and agriculture sector is one of the most heavily regulated in terms of its hygiene standards due to the need for strict disease control and the volume of produce that is used as food, such as milk or eggs. Water is also used as part of the growth and management of crops, the cleaning a sterilising of farm equipment and the cooling and storage of fresh produce.

In the UK, it takes almost 41 billion litres of water to produce one year’s worth of milk. This is because it is an essential part of keeping cattle healthy so that they produce high volumes of good quality milk that is fit to be sold for human consumption. Part of this huge volume of water is to keep dairy sheds clean and to prevent the spread of harmful bacteria that could have catastrophic consequences for a farm if a herd was to be affected.

The sheer volume of the water being wasted by this sector gives it a large scope for potential improvements. Pys.org wrote that “Over 60 per cent of producers” use water inefficiently in the UK alone. According to a study conducted by the Michigan State University, 70% of the water used by the global population goes into the agriculture sector. As a result, there is a consensus within the industry that more needs to be done to eradicate the volume of wastewater that is lost every year as it’s predicted that in the future, water scarcity will be a major issue for the planet as a whole.

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Technologies used in pharmaceutical water treatment

Pharmaceutical water treatment relies on a variety of sophisticated technologies to adhere to the necessary purity standards. These technologies include:

(1). Reverse Osmosis (RO): This method utilizes a semipermeable membrane to eliminate ions, molecules, and larger particles from water, effectively minimizing contaminants.
(2). Ultrafiltration (UF): UF membranes are instrumental in removing bacteria, viruses, and colloids, ensuring microbial purity.
(3). Deionization (DI): Through an ion exchange process involving hydrogen and hydroxide ions, DI eliminates ions from water, resulting in deionized water.
(4). Distillation: By boiling water and then condensing the steam, distillation produces highly pure water, commonly utilized for Water for Injection (WFI) purposes.
(5). Ultraviolet (UV) Disinfection: UV light is employed to deactivate microorganisms by disrupting their DNA, offering an additional layer of microbial control.

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